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EFEITO ANTI-PIRÉTICO
O paracetamol bloqueia o aumento das prostaglandinas E2. Na presença de pirogénios, a concentração de PGE2 no fluído cerebroespinhal aumenta e surge a febre. (1)
(5) Graham, Garry G. et al, The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings, Inflammopharmacol (2013) 21:201–232 DOI 10.1007/s10787-013-0172-x
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